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Home > Human Health Care > Garcinia cambogia Desr.

Garcinia cambogia Desr.

Garcinia cambogia Desr

English name: Garcinia, Gamboge

Family: Clusiaceae

Part used: Fruits

Traditional Uses^1,2:

A decoction of the fruit rind is given in rheumatism and bowel complaints. The fruit rind and extracts of G. cambogia are used in many traditional recipes. In the Ayurvedic system of medicine, some flavours are said to activate digestion and are used as purgatives, in the treatment of worms and parasites, tumours and dysentery. Neither acute nor chronic toxicity is reported with regular consumption of garcinia products as either food or tonics. These products have been used routinely in the coastal areas of South Asia for centuries and they continue to be consumed in large amounts.

Phytochemistry:

The major bioactive constituents of Garcinia cambogia fruit are (-)-hydroxycitric acid and its lactone along with trace amount of citric acid3. The fruit also contains many polyisoprenylated polyphynols viz. garcinol, isogarcinol, camboginol and cambogin4 etc, xanthones viz. garbogiol, rheediaxanthone A5 etc.

Pharmacology:

Garcinia cambogia has been reported for its antiobesity6 activity

Marker constituents:

(-)-Hydroxycitric acid.

Main use: Anti-obesity.

References:


1.	Anonymous. (1998) The Wealth of Asia, Council of Scientific and Industrial Research; New Delhi.
2.	Warrier PK, Nambiar VPK, Ramankutty C. (1995) Indian Medicinal Plants a Compendium of 500 species,
	Orient Longman Ltd., Madras, 3 : 59-61.
3.	Lewis YS, Neelakantan S. (1965) Phytochemistry, 4: 619-625.
4.	Rao AVR, Venkatswamy G, Pendse AD. (1980) Tetrahedron lett. 21: 1975-1978.
5.	Iinuma M, Ito T, Miyake R, et al. (1998) Phytochemistry. 47(6): 1169-1170.
6.	Clouatre D, Rosenbaum M. (1994) The Diet and Health Benefits of HCA, Keals Publishing Inc., New Canaan.
	5-32

DOC NO.

:

NR/QCD/SPC/088

ISSUE DATE

:

02-04-2007

REVISION NO.

:

00

ANALYTICAL SPECIFICATION

NUMBER OF PAGES

:

01

TITLE : GARCINIA CAMBOGIA EXTRACT – Potassium Salt [ ³ 40% (-) HYDROXY CITRIC ACID]

Plant part	:	Fruit
Fresh/Dry	:	Dry

Sl. No.	Tests	Limits	Protocol
1.	Description	Light brown to Brown hygroscopic powder. Soluble in water and dilute acids.
2.	Identification	To pass the test	By HPLC
3.	Physico-chemical analysis	< 10.0	As per USP <921> Method II
	Moisture (%w/w)	< 10.0	As per USP <921> Method II
	Acid insoluble Ash (%w/w)	< 2.0	As per USP<561>
	pH of 1% w/v solution.	7.0 - 11.0	As per USP<791>
4.	Particle Size	0.20 - 0.60	As per USP <616> Method - I
	Bulk density (g/cc)	0.20 - 0.60
	Tapped bulk density (g/cc)	0.20 - 0.80
	Material passing through 30# BS/35 ASTM (%w/w)	> 99.0	As per USP <786> Particle Size distribution.
5.	Heavy metal analysis	< 10 ppm	AAS / ICP -ES
	Lead	< 10 ppm
	Arsenic	< 2 ppm
	Cadmium	< 1 ppm
	Mercury	< 0.1 ppm
6.	Microbiological analysis	< 10⁴cfu g^-1	As per WHO/PHARMA/92.559/Rev.1 Pg.49-52 / As per USP <61> & <62>
	As per FIP Guidelines
	Total Viable Aerobic Count
	Total Enterobacteriaceae	< 10²org g^-1
	Total Fungal Count	< 10²fs g^-1
7.	Test for Specific Pathogen	Absent
	As per FIP Guidelines
	E.coli (1g)
	Salmonella Sp. (10g)	Absent
	S.aureus (1g)	Absent
8.	Mycotoxin analysis	< 5 ppb	As per USP Test for Aflatoxins
8.	Aflatoxins (B₁ + B₂ + G₁ + G₂)	< 5 ppb	As per USP Test for Aflatoxins
9.	Pesticide residue analysis	To comply with USP	As per AOAC / USP
	As per USP & BP Limits
	Organochlorine Pesticides
	Organophosphorus Pesticides
	Synthetic pyrethroids
10.	Phytochemical analysis	³ 40.0	By HPLC
	(-) Hydroxy citric acid (%w/w)	³ 40.0
	Lactone (%w/w)	< 8.0
	Citric acid (%w/w)	< 5.0

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