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Home > Human Health Care > Garcinia cambogia Desr.  
   
Human Health Care
   Garcinia cambogia Desr.
 

Garcinia cambogia Desr
English name: Garcinia, Gamboge
   
Family: Clusiaceae
   
Part used: Fruits
 
   
  Traditional Uses1,2:
 
A decoction of the fruit rind is given in rheumatism and bowel complaints. The fruit rind and extracts of G. cambogia are used in many traditional recipes. In the Ayurvedic system of medicine, some flavours are said to activate digestion and are used as purgatives, in the treatment of worms and parasites, tumours and dysentery. Neither acute nor chronic toxicity is reported with regular consumption of garcinia products as either food or tonics. These products have been used routinely in the coastal areas of South Asia for centuries and they continue to be consumed in large amounts.
   
  Phytochemistry:
 
The major bioactive constituents of Garcinia cambogia fruit are (-)-hydroxycitric acid and its lactone along with trace amount of citric acid3. The fruit also contains many polyisoprenylated polyphynols viz. garcinol, isogarcinol, camboginol and cambogin4 etc, xanthones viz. garbogiol, rheediaxanthone A5 etc.
   
  Pharmacology:
 
Garcinia cambogia has been reported for its antiobesity6 activity
   
  Marker constituents:
 
(-)-Hydroxycitric acid.
   

 

 Main use: Anti-obesity.

   
   
  References:
   
1.
Anonymous. (1998) The Wealth of Asia, Council of Scientific and Industrial Research; New Delhi.
2.
 Warrier PK, Nambiar VPK, Ramankutty C. (1995) Indian Medicinal Plants a Compendium of 500 species,
Orient Longman Ltd., Madras, 3 : 59-61.
3.
Lewis YS, Neelakantan S. (1965) Phytochemistry, 4: 619-625.
4.
 Rao AVR, Venkatswamy G, Pendse AD. (1980) Tetrahedron lett. 21: 1975-1978.
5.
Iinuma M, Ito T, Miyake R, et al. (1998) Phytochemistry. 47(6): 1169-1170.
6.
 Clouatre D, Rosenbaum M. (1994) The Diet and Health Benefits of HCA, Keals Publishing Inc., New Canaan.
5-32

 DOC NO. :  NR/QCD/SPC/087
 ISSUE DATE :  02-04-2007
 REVISION NO. :  00
   ANALYTICAL SPECIFICATION  NUMBER OF PAGES :  01
TITLE : GARCINIA CAMBOGIA EXTRACT – Mg Salt [ ³40% (-) HYDROXY CITRIC ACID]
   Plant part :  Fruit
   Fresh/Dry
 :  Dry

Sl. No.

Tests

Limits

Protocol

1.        

Description

Light brown to brown powder with characteristic odour

2.        

Identification

To pass the test

By HPLC

3.        

Physico-chemical analysis

< 9.0

As per USP <921> Method III

Loss on drying (%w/w)

Acid insoluble Ash (%w/w)

< 2.0

As per USP<561>

pH of 1% w/v solution.

6.0 - 10.0

As per USP<791>

4.        

Particle Size

0.20 -  0.80

As per USP <616> Method - I

Bulk Density (g/cc)

Tapped bulk density (g/cc)

0.40 -  1.20

Material passing through 30# BS/35 ASTM (%w/w)

> 99.0

As per USP <786> Particle Size distribution.

5.        

Heavy metal analysis

< 10 ppm

AAS / ICP -ES

Lead

Arsenic

< 2 ppm

Cadmium

< 1 ppm

Mercury

< 0.1 ppm

6.        

Microbiological analysis

< 104  cfu g-1

As per WHO/PHARMA/92.559/Rev.1 Pg.49-52 / As per USP <61> & <62>

As per FIP Guidelines

Total Viable Aerobic Count

Total Enterobacteriaceae

< 102  org g-1

Total Fungal Count

< 102  fs g-1

7.        

Test for Specific Pathogen

 

As per FIP Guidelines

E.coli (1g)

Absent

Salmonella Sp. (10g)

Absent

S.aureus (1g)

Absent

8.        

Mycotoxin analysis

< 5 ppb

As per USP Test for Aflatoxins

Aflatoxins (B1 + B2 + G1 + G2)

9.        

Pesticide residue analysis

To comply with USP

As per AOAC / USP

As per USP & BP Limits

Organochlorine Pesticides

Organophosphorus Pesticides

Synthetic pyrethroids

10.     

Phytochemical analysis

³ 40.0

By HPLC

(-) Hydroxy citric acid (%w/w)

Lactone (%w/w)

< 8.0

Citric acid (%w/w)

< 5.0


 DOC NO. :  NR/QCD/SPC/040
 ISSUE DATE :  02-04-2007
 REVISION NO. :  00
   ANALYTICAL SPECIFICATION  NUMBER OF PAGES :  01
TITLE : GARCINIA CAMBOGIA EXTRACT – Mg Salt [ ³50% (-) HYDROXY CITRIC ACID]
   Plant part :  Fruit
   Fresh/Dry
 :  Dry

Sl. No.

Tests

Limits

Protocol

1.        

Description

Light brown to brown powder with characteristic odour

2.        

Identification

To pass the test

By HPLC

3.        

Physico-chemical analysis

< 9.0

 

As per USP <921> Method III

Loss on drying (%w/w)

Acid insoluble Ash (%w/w)

< 2.0

As per USP<561>

pH of 1% w/v solution.

6.0 - 10.0

As per USP<791>

4.        

Particle Size

0.20 -  0.80

As per USP <616> Method - I

Bulk Density (g/cc)

Tapped bulk density (g/cc)

0.40 -  1.20

Material passing through 30# BS/35 ASTM (%w/w)

> 99.0

As per USP <786> Particle Size distribution.

5.        

Heavy metal analysis

< 10 ppm

AAS / ICP -ES

Lead

Arsenic

< 2 ppm

Cadmium

< 1 ppm

Mercury

< 0.1 ppm

6.        

Microbiological analysis

< 104  cfu g-1

As per WHO/PHARMA/92.559/Rev.1 Pg.49-52 / As per USP <61> & <62>

As per FIP Guidelines

Total Viable Aerobic Count

Total Enterobacteriaceae

< 102  org g-1

Total Fungal Count

< 102  fs g-1

7.        

Test for Specific Pathogen

 

As per FIP Guidelines

E.coli (1g)

Absent

Salmonella Sp. (10g)

Absent

S.aureus (1g)

Absent

8.        

Mycotoxin analysis

< 5 ppb

As per USP Test for Aflatoxins

Aflatoxins (B1 + B2 + G1 + G2)

9.        

Pesticide residue analysis

To comply withUSP

As per AOAC / USP

As per USP & BP Limits

Organochlorine Pesticides

Organophosphorus Pesticides

Synthetic pyrethroids

10.     

Phytochemical analysis

³ 50.0

By HPLC

(-) Hydroxy citric acid (%w/w)

Lactone (%w/w)

< 8.0

Citric acid (%w/w)

< 5.0


 
             
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