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| A
new generation uterine tonic & ecbolic
with high phytochemical actives |
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STUDIES REVEAL.......... |
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LAB STUDIES : |
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1) Myometrial Contraction
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OBJECTIVES :
To assess the action of INVOLON in inducing
myometrial contractions. |
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Uterine horn
from diethyl stilbesterol primed rat was mounted
in an isolated organ bath. The isolated uterus
was allowed to equilibrate for 30 minutes
and exposed to submaximal dose of oxytocin
0.1 ml. (0.05 I.U) & later INVOLON solution
5% - 0.1 ml. & 0.05 ml. The magnitude
of uterine contractions were recorded. It
was observed that 2.5 mg. of INVOLON was equivalent
to 0.05 I.U. of oxytocin in terms of magnitude
of uterine contractions. |
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2) Uterotonic Effect : |
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OBJECTIVES :
To evaluate uterotonic activity of INVOLON. |
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To assess the
dose response curve and to arrive at most
suitable dose having maximum response &
extrapolating the same to cattle dosage.
At 12th day of pregnancy,
female rats were treated with INVOLON at different
dose rate starting from 5 mg to 40 mg / kg
rat body weight for 3 consecutive days. On
17th day of pregnancy, uteri were examined
for resorbed or degenerated foetus. Gravid
uterus needs to be flacid for maintainance
of pregnancy. Increased tonicity of uterus
is detrimental to growing foetus. Hence, percent
of degenerated foetus / failure of pregnancy
was considered as a standard parameter to
assess the uterotonic effect of the test
product. Of all the dose rates tested, 10
mg / kg rat body weight showed maximum uterotonic
activity which works out to be more or less
550 mg per adult cow.
Interpretation of
lab studies: Pharmacological evaluation
of INVOLON in lab animals as mentioned earlier,
has proved its uetro tonic and ecbolic actions.
Uterine tonicity and contractions play key
role in separation of placental membranes
and subsequent expulsion. INVOLON by toning
up the uterus and inducing the uterine contractions
prevents uterine inertia and thereby RPM. |
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Field Studies… |
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An Invitro experiment was studied
on INVOLON Bolus in pregnant female rats. |
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Observations : |
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| Group |
Total
No. of foetus |
Average
No. of foetus |
Degenerated |
%
failure |
%
inhibition |
| CONTROL |
73 |
10.4 |
5 |
6.8 |
- |
| 5 mg./kg. |
34 |
8.5 |
2 |
5.9 |
-13.2 |
| 10 mg./kg. |
80 |
10.0 |
14 |
17.5 |
157.0 |
| 20 mg./kg. |
69 |
9.9 |
6 |
8.6 |
26.5 |
| 40 mg./kg. |
66 |
9.4 |
3 |
4.5 |
-33.0 |
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-(H.V.Ramesh Babu,
Nisha Kamath, Nanjaraje Urs.S., Jayashree Gopal) |
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INVOLON was
tried in 24 freshly calved crossbred cows.
Administration of INVOLON to freshly calved
crossbred cows helped in quick (on an average
24 hrs.) expulsion of placenta. It has also
helped in cotyledonary-carencular seperation
leading to easy manual removal. |
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-(Dr.G.R.Prakash,
Vety. Officer, Kaiwar, Chintamani Tq.) |
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INVOLON Bolus
was tried in 10 animals. Administration of
INVOLON Bolus resulted in timely placental
shedding and also helped in easy manual removal
of placenta. |
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-(Dr.R.M.Gowda,
Vety. Hospital, Gavipuram, Bangalore) |
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INVOLON Bolus
was tried in 10 animals. From the results
it was concluded that INVOLON Bolus is very
effective in providing complete postpartum
care i.e. early shedding of placenta, regulation
on lochial discharge, early onset of postpartum
heat and overall improvement in breeding efficiency
and was further concluded that INVOLON Bolus
is an efficient and safe drug and can be recommended
under field conditions for prevention of postpartum
disorders. |
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-(Dr.R.K.Sonawane,
V.A.S., Bhilai) |
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INVOLON Bolus
was tried in 5 freshly calved cows. It was
concluded that INVOLON enhances the contraction
of uterine musculature thereby early expulsion
of placenta and early cleaning of uterus.
These phenomenon results in quiet early uterine
involution and animal come in cycle earlier
than normal one. All these help to improve
the breeding efficiency, and hence improves
the profits. |
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-(Dr.P.T.Kakadia,
Vety. Officer, Gondal) |
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THESIS ABSTRACT |
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| Title
of thesis: |
“STUDIES
ON PLACENTAL EXPULSION & UTERINE
SOUNDNESS IN FRIESWAL
COWS”.
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| Full
name of student: |
Savita
Tiwari |
| Name
and address of major advisor: |
DR.
R. K. PANDIT
HEAD, DEPT. OF OBSTETRICS
& GYNAECOLOGY
VETERINARY COLLEGE
JABALPUR – 482 001
(M.P.)
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| Degree
to be awarded: |
M.V.Sc.
(Obstetrics & Gynaecology) |
| Year
of award of degree: |
1999 |
| Major
Subject: |
Obstetrics
& Gynaecology |
| Total
number of pages in thesis abstract: |
1 |
| Name
of forwarding authority: |
DR.
R. K. PANDIT
HEAD DEPT. OF OBSTETRICS
& GYNAECOLOGY
VETERINARY COLLEGE,
JABALPUR – 482 001
(M.P.)
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ABSTRACT |
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The study
was conducted on the Frieswal (Holstein Friesian
x Sahiwal) cows belonging to the Military
Dairy Farm, Jabalpur. For the treatment of
retention of placenta, 40 pregnant cows were
allotted randomly with equal number to the
2 groups. To the cows of first group, INVOLON
Bolus was administered 1 bid x 3 days, orally,
after calving. Second group was kept as untreated
control. |
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In the INVOLON
treated group all the cows expelled their
placenta within 6.08 ± 0.31 hours postpartum
compared to 8.66 ± 0.56 hours in the
control group. Disappearance of lochia / occurrence
of first postpartum oestrus (8.40 ±
0.60 days / 55.9 ± 3.20 days) were
significantly earlier (P < 0.05) in the
treated group than the untreated control (9.90
± 1.25 days / 60.90 ± 5.76 days).
The treatment caused significantly earlier
(P < 0.01) uterine involution / service
period (20.07 ± 0.67 days / 71.56 ±
3.60 days) compared to control group (29.35
± 0.35 days / 87.30 ± 4.30 days).
The 90 days milk production was also significantly
more
(P < 0.01) in INVOLON treated group (1216.95
± 72.13 litres) than the control (1012.4
± 85.17 litres). The conception rate
was comparatively better in the INVOLON treated
group (1.70 ± 0.21) compared to untreated
control group (2.40 ± 0.17). |
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INVOLON Bolus
was tried in 20 pregnant frieswal cows. INVOLON
treated cows expelled their placenta within
6.08±0.31 hours postpartum compared
to 8.66±0.56 hours in the control group.
It was concluded that INVOLON is claimed to
be an ecbolic and uterotonic in action, hence
it helped in early involution of uterus along
with better subsequent reproductive and productive
performance. Apart from this, INVOLON also
improved the milk yield being galactogogue
also in action. |
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THESIS
ABSTRACT |
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| Title
of thesis: |
“STUDIES
ON RETENTION OF FOETAL MEMBRANES IN
BUFFALOES, EFFECT OF SOME DRUGS
ON UTERINE CONTRACTION IN VITRO
AND
EXPULSION OF FOETAL MEMBRANES”.
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| Full
name of student: |
Rajendra Prasad
Gautam |
| Name
and address of major advisor: |
DR.
R. P. TIWARI
CHAIRMAN, ADVISORY COMMITTEE
DEPT. OF OBSTETRICS & GYNAECOLOGY
VETERINARY COLLEGE, ANJORA
DURG (C.G.)
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| Degree
to be awarded: |
M.V.Sc. (Obstetrics
& Gynaecology) |
| Year
of award of degree: |
2000 |
| Major
Subject: |
Obstetrics
& Gynaecology |
| Total
number of pages in thesis abstract: |
1 |
| Name
of forwarding authority: |
DR.
R. P. TIWARI
CHAIRMAN, ADVISORY COMMITTEE
DEPT. OF OBSTETRICS & GYNAECOLOGY
VETERINARY COLLEGE, ANJORA
DURG (C.G.)
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ABSTRACT |
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In vivo studies
was conducted to evaluate the effect of herbal
drugs on different reproductive performance.
The time required for expulsion of foetal
membranes (hrs.) in buffaloes in control group
was higher (7.33 ? 0.74 hrs.) as compared
to group treated with INVOLON (4.71 ? 0.52
hrs). The difference in the mean time required
for expulsion of foetal membranes between
control and INVOLON was significant. |
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The mean time interval required
for disappearance of lochia was 10.83 ? 0.55
days in control group. While it was 9.71 ? 0.48
days in INVOLON treated group. |
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Time required
for involution of uterus in control group
was 49.00 ? 2.20 days. While it was 43.20
? 3.13 days in INVOLON treated group. |
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The onset
of first post partum estrus in control group
was 64.00 ? 4.08 days. The onset of first
post partum estrus in INVOLON was 64.33 ?
3.18 days. |
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