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English
Name: Mango |
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English
Name: Mango |
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Part
used: Bark |
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Traditional
Uses: |
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mango
leaves were used to relieve the
pain of scorpion stings and the
unripe fruit to help heal a wide
variety of skin eruptions, ranging
from leprosy and sores to boils
and cysts1. The inner
bark is used for treating mouth
sores; It is also used for lesions
of the urinary-genital area. The
pulp of the ripe fruit is used as
a poultice for tender reasts and
sore nipples.2 The mango
bark is astringent, used in uterine
haemorrhage, haemoptysis and haemorrhagic
diarrhoea.3 |
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Phytochemistry
4: |
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Protocatechuic
acid, catechin, mangiferin, alanine,
glycine, γ-aminobutyric
acid, kinic acid, shikimic acid,
tetracyclic triterpenoids |
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Pharmacology: |
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Mangifera
indica has been reported to
have anti diabetic5-7,
antioxidant8-11, analgesic12,
anti-inflammatory13,
and antidiarrhoeal14
activities. It also possess antimicrobial,
antiamoebic15, antiviral16,
immunomodulatory17 and
cardioprotective effects18.
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Indication: Blood
sugar management, antioxidant, and
weight loss management. |
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References: |
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1. |
Colonel Sir
R.N. Chopra, M.D., et al. Chopra's
Indigenous Drugs of India. Calcutta:
U.N. Dhur and |
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Sons
Ltd. 1958. |
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2. |
George Uhe.
"Medicinal plants of Samoa."
Economic Botany 28:8 January-March
1974. |
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3. |
Satyavati GV
and Ashok KG. 1987. Medicinal Plants
of India, Indian council of medical
research, New |
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Delhi.
Vol.2. |
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4. |
Paolo S and
Ester S. Journal of Ethnopharmacology.
2000: 71: pp 22-43. |
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5. |
Muruganandan
S et al, Effect of mangiferin on hyperglycemia
and atherogenicity in streptozotocin
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diabetic
rats, J Ethnopharmacol. 2005 Mar 21;
97(3):497-501. |
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6. |
Aderibigbe
AO et al, Evaluation of the antidiabetic
action of Mangifera indica in mice,
Phytother Res. |
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2001,
15(5):456-8. |
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7. |
Aderibigbe
AO et al, Antihyperglycaemic effect
of Mangifera indica in rat, Phytother
Res. 1999 Sep; |
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13(6):504-7. |
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8. |
Martínez
G, Delgado R, Pérez G, et al.
2000. Evaluation of the in vitro antioxidant
activity of |
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Mangifera
indica L. extract (Vimang). Phytother
Res 14: 424–427. |
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9. |
Sánchez
GM, Delgado R, Pérez G, et
al. 2000a. Evaluation of the in vitro
antioxidant activity of |
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Mangifera
indica L. extract (Vimang). Phytother
Res 14: 424–427. |
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10. |
Sánchez
GM, Re L, Giuliani A, et al. 2000b.
Protective effects of Mangifera indica
L. extract |
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mangiferin
and selected antioxidants against
TPA-induced biomolecules oxidation
and peritoneal |
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macrophage
activation in mice. Pharmacol Res
42: 565–573. |
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11. |
Jagetia GC
and Venkatesha VA. Environ Mol Mutagen.
2005 Jul; 46(1):12-21. |
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12. |
Garrido G,
Gon¸alez D, Delporte C, et al.
2001. Analgesic and anti-inflammatory
effects of Mangifera |
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indica L. extract
(Vimang). Phytother Res 15: 18–21. |
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13. |
Das PC, Das
A, Mandal S. 1989. Anti-inflammatory
and antimicrobial activities of the
seed kernel of |
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Mangifera
indica extract. Phytother Res LX:
235–240. |
| 14. |
Sairam K, Journal
of Ethno pharmacology 84, 2003, 11-15. |
| 15. |
Leiro JM et
al., Biochemical Pharmacology. 2003:
65: pp 1361–1371. |
| 16. |
Zhu XM, Zhongguo
Yao Li Xue Bao. 1993 Sep; 14(5):452-4. |
| 17. |
Makare, et
al, Journal of Ethnopharmacology,
78, 2001, 133-137. |
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| 18. |
Prabhu
et al, Vascul Pharmacol. 2006:
44(6): pp 519-525 |
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| Immunomodulatory. |
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Anti-inflammatory |
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Anti-diabetic |
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Kar,
A Choudhary, B.K. and Bandyopadhyay,
N.G. 1999. Preliminary studies
on the inorganic constituents
of some indigenous hypoglycaemic
herbs on oral glucose tolerance
test. J Ethnopharutacol 64:
179-184. |
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Anti-allergic |
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Gupta,
P.P., Srimal, R.C. and Tandon,
J.S. 1993. Antiallergic activity
of some traditional Indian
medicinal plants. Int J Pharmacog
31: 15-18. |
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Anti-microbial
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DOC
NO. |
: |
NR/QCD/SPC/051 |
| ISSUE
DATE |
: |
02-04-2007 |
| REVISION
NO. |
: |
00 |
|
| ANALYTICAL
SPECIFICATION |
NUMBER
OF PAGES |
: |
01 |
| TITLE
: MANGIFERA INDICA
EXTRACT (³ 20%
MANGIFERIN) |
| Plant
part |
: |
Bark |
| Fresh/Dry |
: |
Dry |
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Sl. No. |
Tests |
Limits |
Protocol |
| 1. |
Description |
Light
brown to Dark brown
powder |
| 2.
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Identification |
To pass the test |
By TLC |
| 3.
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Physico-chemical
analysis |
< 10.0 |
As per USP <921> Method II |
| Moisture
(%w/w) |
| Ash
content (%w/w) |
< 5.0 |
As per USP <561> |
| Acid
insoluble Ash (%w/w) |
< 1.5 |
As per USP <561> |
| 4. |
Particle
Size |
0.20 - 0.60 |
As per USP <616> Method -
I |
| Bulk
Density (g/cc) |
| Tapped
bulk Density (g/cc) |
0.20 - 0.80 |
| Material passing through 30# BS/35 ASTM (%w/w) |
> 99.0 |
As per USP <786> Particle Size distribution. |
| 5. |
Heavy
metal analysis |
< 10 ppm |
AAS / ICP -ES |
| Lead |
| Arsenic |
< 2 ppm |
| Cadmium |
< 1 ppm |
| Mercury |
< 0.1 ppm |
| 6. |
Microbiological
analysis |
< 104 cfu g-1 |
As per WHO/PHARMA/92.559/Rev.1
Pg.49-52 / As
per USP <61> &
<62> |
| As per FIP Guidelines
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| Total
Viable Aerobic Count |
| Total
Enterobacteriaceae |
< 102 org g-1 |
| Total
Fungal Count |
< 102 fs g-1 |
| 7. |
Test
for Specific Pathogen |
Absent |
| As per FIP Guidelines |
| E.coli (1g) |
| Salmonella
Sp.
(10g) |
Absent |
| S.aureus (1g) |
Absent |
| 8. |
Mycotoxin
analysis |
< 5 ppb |
As per USP Test for Aflatoxins |
| Aflatoxins
(B1 + B2
+ G1 + G2) |
| 9. |
Residual
solvent analysis |
< 3000 |
As per USP |
| As per ICH Guidelines |
| Methanol
(ppm) |
| 10. |
Pesticide
residue analysis |
To comply with USP |
As per AOAC / USP |
| As per USP & BP
Limits |
| Organochlorine
Pesticides |
| Organophosphorus
Pesticides |
| Synthetic
pyrethroids |
| 11. |
Phytochemical
analysis |
> 20.0 |
By HPLC |
| Mangiferin
(%w/w) |
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DOC
NO. |
: |
NR/QCD/SPC/156 |
| ISSUE
DATE |
: |
02-04-2007 |
| REVISION
NO. |
: |
00 |
|
| ANALYTICAL
SPECIFICATION |
NUMBER
OF PAGES |
: |
01 |
| TITLE
: MANGIFERA INDICA
EXTRACT (³ 80%
MANGIFERIN) |
| Plant
part |
: |
Bark |
| Fresh/Dry |
: |
Dry |
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Sl. No. |
Tests |
Limits |
Protocol |
| 1. |
Description |
Greenish
yellow to Brownish yellow
powder with characteristic
odour |
| 2.
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Identification |
Positive for Mangiferin |
By TLC |
| 3.
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By HPLC |
| 4.
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Physico-chemical
analysis |
< 5.0 |
As per USP <561> |
| Ash
content (%w/w) |
| Acid
insoluble Ash (%w/w) |
< 1.5 |
| 5. |
Particle
Size |
0.20 - 0.80 |
As per USP <616> Method -
I |
| Bulk
Density (g/cc) |
| Tapped
bulk Density (g/cc) |
0.25 - 0.95 |
| Material passing through 30# BS/35 ASTM (%w/w) |
> 99.0 |
As per USP <786> Particle Size distribution. |
| 6. |
Heavy
metal analysis |
< 10 ppm |
AAS / ICP -ES |
| Lead |
| Arsenic |
< 2 ppm |
| Cadmium |
< 1 ppm |
| Mercury |
< 0.1 ppm |
| 7. |
Microbiological
analysis |
< 104 cfu g-1 |
As per WHO/PHARMA/92.559/Rev.1
Pg.49-52 / As
per USP <61> &
<62> |
| As per FIP Guidelines
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| Total
Viable Aerobic Count |
| Total
Enterobacteriaceae |
< 102 org g-1 |
| Total
Fungal Count |
< 102 fs g-1 |
| 8. |
Test
for Specific Pathogen |
Absent |
| As per FIP Guidelines |
| E.coli (1g) |
| Salmonella
Sp.
(10g) |
Absent |
| S.aureus (1g) |
Absent |
| 9. |
Mycotoxin
analysis |
< 5 ppb |
As per USP Test for Aflatoxins |
| Aflatoxins
(B1 + B2
+ G1 + G2) |
| 10. |
Residual
solvent analysis |
< 3000 |
As per USP |
| As per ICH Guidelines |
| Methanol
(ppm) |
| 11. |
Pesticide
residue analysis |
To comply with USP |
As per AOAC / USP |
| As per USP & BP
Limits |
| Organochlorine
Pesticides |
| Organophosphorus
Pesticides |
| Synthetic
pyrethroids |
| 12. |
Phytochemical
analysis |
> 80.0 |
By HPLC |
| Mangiferin
(%w/w) |
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