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English
name: Pomegranate |
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Family:
Punicaceae |
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Part
used: Fruit-peel |
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Punica
is used in Mexican traditional
medicine for the treatment of
gastrointestinal disorders1.
The peels are powerful astringent
and cure for diarrhea, oral
aphthae. Juice is a refrigerant
which lowers fever2
and it is a blood tonic3.
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Punica granatum consists
of glucosides, tannin, ursolic
acid, carbohydrates, carotene,
pectin, protein, riboflavin,
ellagic acid, gallic acid, glutamine,
tannins( like punicalgins and
punicalin), sitosterol and its
ß-D-glucoside,etc.
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Punica
granatum is reported to
have antioxidant5-9,
anti-atherosclerotic10-12,
antibacterial13,
anthelmintic14, antiviral15.
It is also used in oral hygiene16,
anti obesity17 and
as an adjunct therapy to increase
bioavailability of radioactive
dyes during diagnostic imaging.18-19.
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Antioxidant
and heart health.
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References: |
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| 1. |
Calzada F,J Ethnopharmacol.
2006,108(3):367-70. Epub.
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2. |
Arseculeratne,
S.N., Gunatilaka, A.A.L.,
Panabokke, R.G., 1985. Studies
on medicinal plants of Sri
Lanka. |
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Part 14. Toxicity
of some traditional medicinal
herbs. Journal of Ethnopharmacology
13, 323–335. |
| 3. |
Lad, V., Frawley, D., 1986.
The Yoga of Herbs. Lotus
Press, Santa Fe, NM, pp.
135-136. |
| 4. |
Database on
Medicinal plants used in Ayurveda,
Vol-2, New Delhi, CCRAS, 2001.page
no. 177. |
| 5. |
Reddy MK, et al, Planta
Med. 2007 ,73(5):461-7. |
6. |
Faria A et
al, Eur J Nutr. 2007 ,46(5):271-8. |
| 7 |
Guo S et al,
J Agric Food Chem. 2007 ,18;55(8):3134-40. |
8. |
Rout S, Banerjee
R, Bioresour Technol. 2007,
98(16):3159-63. |
9. |
Ricci D et
al, Fitoterapia. 2006 ,77(4):310-2. |
10. |
Aviram et al,
Clinical Nutrition, 23, 423
– 433 (2004). |
11. |
Kaplan et
a.,. Biochem. Mol. Act. Nutr.
2001 |
12. |
Napoli et
al Proc. Natl. Acad. Sci,
102, 4896 – 4901 (2005) |
| 13. |
Pérez,
C. and Anesini, C. (1994).
In vitro antibacterial activity
of Argentinean folk medicinal
plants against |
|
Salmonella
typhi, J.Ethnopharmacol, 44,
41-46 |
14. |
Naovi, S.A.H.,
Khan, M.S.Y. and Vohora, S.B.
(1991). Antibacterial, antifungal
and anthelmintic |
|
investigations
on Indian medicinal plants.Fitoterapia,
62,221-228. |
15. |
Zhang, J. (1995).
Antiviral activity of tannin
from pericarp of Punica granatum
against genital Herpes |
|
simplex virus
in vitro. China journal of
Chinese material Medica, 20,556-558. |
16. |
Menezes SM
et al, 1: J Herb Pharmacother.
2006;6(2):79-92. |
17. |
Lei F et al, Int
J Obes (Lond). 2007, 31(6):1023-9. |
18. |
Il'iasov, T.N., 1975. Vestnik
Rentgenologii i Radiologii
5, 83-84. |
19. |
Amorim, L.F et al,2003, Cellular and Molecular Biology 49,
501-507. |
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DOC
NO. |
: |
NR/QCD/SPC/113 |
| ISSUE
DATE |
: |
02-04-2007 |
| REVISION
NO. |
: |
00 |
| ANALYTICAL
SPECIFICATION |
NUMBER
OF PAGES |
: |
01 |
| TITLE
:
PUNICA
GRANATUM EXTRACT
(³
40% ELLAGIC ACID)
|
| Plant
part |
: |
Fruit rind |
Fresh/Dry
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: |
Dry |
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Sl. No. |
Tests |
Limits |
Protocol |
| 1.
|
Description |
Light
yellowish brown to Dark
brown powder |
| 2.
|
Identification |
To pass the test |
By HPLC |
| 3.
|
Physico-chemical
analysis |
< 7.0 |
As per USP <921> Method II |
| Moisture
(%w/w) |
| Acid
insoluble Ash (%w/w) |
< 2.5 |
As per USP<561> |
| Total
Ash %(w/w) |
< 5.0 |
| 4.
|
Particle
Size |
0.25 - 0.70 |
As per USP <616> Method -
I |
| Bulk
Density (g/cc) |
| Tapped
bulk density |
0.30 - 0.90 |
| Material passing through 30# BS/35 ASTM (%w/w) |
> 99.0 |
As per USP <786> Particle Size distribution. |
| 5.
|
Heavy
metal analysis |
< 10 ppm |
AAS / ICP -ES |
| Lead |
| Arsenic
|
< 2 ppm |
| Cadmium
|
< 1 ppm |
| Mercury |
< 0.1 ppm |
| 6.
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Microbiological
analysis |
< 104 cfu g-1 |
As per WHO/PHARMA/92.559/Rev.1
Pg.49-52 / As
per USP <61> &
<62> |
| As per FIP Guidelines
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| Total
Viable Aerobic Count |
| Total
Enterobacteriaceae |
< 102 org g-1 |
| Total
Fungal Count |
< 102 fs g-1 |
| 7.
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Test
for Specific Pathogen |
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| As per FIP Guidelines |
| E.coli (1g) |
Absent |
| Salmonella
Sp.
(10g) |
Absent |
| S.aureus (1g) |
Absent |
| 8.
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Mycotoxin
analysis |
< 5 ppb |
As per USP Test for Aflatoxins |
| Aflatoxins
(B1 + B2
+ G1 + G2) |
| 9.
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Residual
solvent analysis |
< 3000 |
As per USP |
| As per ICH Guidelines |
| Methanol
(ppm) |
| 10.
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Pesticide
residue analysis |
To comply with USP |
As per AOAC / USP |
| As per USP & BP
Limits |
| Organochlorine
Pesticides |
| Organophosphorus
Pesticides |
| Synthetic
pyrethroids |
| 11.
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Phytochemical
analysis |
³ 40 |
By HPLC |
| Ellagic acid (%w/w) |
| Punicalagin (% w/w) |
³ 0.5 |
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