Standardized / custom programs of preclinical discovery solutions to meet the needs of the Pharmaceutical, Natural Product and Biotechnology Industries. We have standardized and routinely perform more than 50 in-vitro assays relevant to selection and optimization of new drug candidates using specialized assay technologies based on different detection modes like Absorbance (colorimetric, ELISA), Luminescence and Fluorescence (Fluorescence Intensity, Fluorescence Polarization, Time Resolved Fluorescence etc) in 96 and 384 well formats. We provide a spectrum of these services in cellular assays that are designed to accelerate the pace and increase the productivity of discovery and development programs. We are committed in providing high quality, cost effective in vitro services with a rapid turnaround time. Apart from new product development, cell assays can be effectively be used for screening campaigns, bio-activity guided fractionation, compatibility studies, stability studies and for comparing various prototypes/formulations. In-vitro efficacy studies helps to screen the drug for its various therapeutic applications using high throughput model, thereby cost effective, repoducible results can be generated. In-vitro preclinical safety studies are standardized according to OECD guideline. These assays facilitates to explore the genotoxic potential of molecule.

Screening and assay development remains one of the most challenging and resource-intensive steps in the drug discovery process, with the end result depending on proper balance of assays, experimental design, and data management. Natural Remedies provides a broad spectrum of high quality service to support various stages of drug discovery and development. With state-of-the-art facilities and instrumentation, we offer services in assay development, compound profiling and in vitro safety. Natural Remedies uses a number of primary and immortalized cell lines to assay test compounds. We have 50 validated in vitro assays targeting various therapeutic areas using specialized assay technologies based on different detection models like absorbance (Colorimetric,ELISA), Luminescence and Fluorescence (Fluorescence Intensity, Fluorescence Polarization, Time Resolved Fluorescence) in 96 and 384 well formats. Using these in vitro cell based assays, compounds can be rapidly and cost effectively screened for activity prior to more expensive and time consuming in vivo analysis.

Safety assessment is an important criterion for compound development before expensive preclinical and clinical studies. In order to predict Genotoxicity or specific cellular impacts, Natural Remedies provides in vitro genetic testing (Ames, Chromosome Aberration, Micronucleus).

All work is carried out under well-defined standard operating procedures (SOPs) by highly qualified scientists. Most studies can be conducted under Good Laboratory Practice (GLP) compliance if required.