Natural support to manage symptoms of common cold (Immune support)

AP-Bio® is clinically tested phytochemical composition derived from Andrographis paniculata, a widely used plant in Ayurveda. AP-Bio® is standardized to andrographolide and other diterpene lactones.

WHAT IS AP-Bio®

Andrographis paniculata, widely used in India and China as traditional medicine for managing common cold symptoms like that include cough, expectoration, nasal discharge, headache, fever, sore throat, ear ache, sleep disturbance and malaise/fatigue.

Most of the commonly used cold remedies target only 1 or 2 symptoms.

AP-Bio® is known to support in the management of multiple symptoms of common cold with faster onset of action. It is standardized into 7 phyto- constituents -Andrographolide, Isoandro grapholide, Neoandrographolide, 14-deoxy-11,12 Didehydroandrographolide, Andrograpanin, Skullcapflavone-I and 7-O-Methylwogonin.

CLINICAL STUDY

Randomized double- blind placebo controlled clinical study of AP-Bio® with 223 adults suffering from two or more symptoms of common cold and gave treatment for 5 days.

This graph shows the overall symptoms score wherein AP-Bio® showed significant reduction compared to placebo.

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AP-Bio® was found to be 2 times more effective than placebo in managing the symptoms of common cold.

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PRE- CLINICAL STUDY

Effect of AP-Bio® on inflammatory mediators

Based on pre-clinical studies, the effect of AP-Bio® was studied on LPS induced immune cells which reduced the levels of inflammatory mediators like NO, PGE 2 , IL-1 beta and IL-6 in J774A.

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AP-Bio® inhibits the release of inflammatory mediators

MODES OF ACTION

AP-Bio® possibly acts by inhibiting the release of inflammatory mediators viz., LTB4, PGE2, TXB2, IL-6, IL-1β and Nitric oxide.

INFLAMMATORY MEDIATORS LINKED TO
LTB4 Bronchoconstriction, inflammation and mucus secretion
PGE2, TXB2 Bronchoconstriction and inflammation
Cytokines (IL-6, IL-1β) Bronchoconstriction, inflammation, mucus secretion & sore throat
Nitric oxide Bronchoconstriction, inflammation and cell migration

HEALTH BENEFITS AND DOSE

Natural support to manage symptoms of common cold (Immune support)

Dose

100 mg twice a day

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