Gutgard® is an innovative, clinically researched, bioactive for gut health. As opposed to focusing solely on deglycyrrhization, Gutgard® is a flavonoid-rich extract of G. glabra root. It is entirely different from deglycyrrhized licorice (DGL) with respect to chemistry and composition, manufacturing process, mechanisms of action and physicochemical properties.

WHAT IS GUTGARD®

Gutgard® is extracted using a soft and unique extraction process to capture the bioactive flavonoid chemistry of the plant. A classical extract like DGL does not contain any significant quantity of flavonoids. Most of the generic DGL-based extracts available in the market are by-products of a process to manufacture glycyrrhizin from licorice.

Gutgard® is standardized to contain ≥10% total flavonoids (w/w) and also ≤0.5% glycyrrhizin to avoid undesirable side effects. More than 50 flavonoids have been identified in Gutgard® by hyphenated analytical techniques like LC-MS, including isoflavans (glabridin), flavones (ex: licoflavone A), flavanones (ex: glabrol), chalcones (Ex: isoliquiritigenin), isoflavones (ex: Formononetin), etc. Batch to batch consistency of the flavonoid profile is monitored with the help of HPLC and other advanced analytical test methods. Licorice flavonoids have been shown to have beneficial activity for digestive complaints. Gutgard® itself has been clinically tested and shown to have efficacy for addressing these complaints. Gutgard® (with LC-MS based identification of flavonoids) showed far superior antiulcer (in-house report) and anti-Helicobacter pylori activity than regular aqueous based deglycyrrhizinated (DGL) extracts. Because of the concentrated nature of the flavonoids, the efficacious intake level for Gutgard® is much lower than that needed for DGL – 150 mg/day versus 1500 mg/day.

CLINICAL STUDY

MODES OF ACTION

Acts as prokinetic agent
Modulates gut motility

1

Works against H. pylori  – In vitro ( Inhibits H. pylori Protein synthesis, DNA gyrase & dihydrofolate reductase)

2

Acts as gastroprotective agent  – Reduces inflammatory Mediators like PGE, TXB, LTB, NO, IL –1 beta and IL-6. Possess anti-oxidant properties (Inhibits DPPH,ABTS) and possess good ORAC

3

HEALTH BENEFITS AND DOSE

Supports gut health

Helps manage occasional indigestion including fullness & gas

Supports management of H. pylori

Helps manage occasional heartburn

Dose

150 mg per day

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