As researchers try to predict the absorption, distribution, metabolism and excretion (ADME) characteristics of a compound, the advent of various in-vitro high throughput assays has come as a boon. The liver is the central organ in ADME. It is responsible for most of the metabolic processes involving the breakdown of drugs and their excretion from the body. The cytochrome P450 superfamily of enzymes sits at the crossroads of liver metabolism, encompassing dozens of gene products that catalyze the breakdown of drugs and toxins. We at Natural Remedies have standardized several Cytochrome P450 assays that are useful for studying interaction as well as metabolism. In addition, we have standardized various in-vitro permeability models like PAMPA and Caco-2 monolayer permeability assay that are useful for absorption studies.

Standardized/custom programs of preclinical discovery solutions to meet the needs of the Pharmaceutical, Natural Product and Biotechnology Industries. Biochemical/Enzyme inhibition assays are biological methods through which the bioactivity of test substances can be assessed.

In the preclinical discovery market, the versatility of enzyme-based assays, a lesser turnaround time and low costs influence most companies to choose enzyme based assays over others. This unit has standardized and routinely perform more than 70 validated in-vitro assays targeting various therapeutic areas using specialized assay technologies based on different detection models like absorbance (Colorimetric, ELISA), Luminescence and Fluorescence (Fluorescence Intensity, Fluorescence Polarization, Time-Resolved Fluorescence) in 96 and 384 well formats. We provide a spectrum of these services in cellular assays that are designed to accelerate the pace and increase the productivity of discovery and development programs.

Screening and assay development remains one of the most challenging and resource-intensive steps in the drug discovery process, with the end result depending on the proper balance of assays, experimental design, and data management. Natural Remedies provides a broad spectrum of high-quality service to support various stages of drug discovery and development.

With state-of-the-art facilities and instrumentation, we offer services in assay development, compound profiling and in vitro safety. Natural Remedies uses a number of primary and immortalized cell lines to assay test compounds. We are committed to providing high quality, cost-effective in vitro services with a rapid turnaround time.

Using these in vitro cell based assays, compounds can be rapidly and cost effectively screened for activity prior to more expensive and time-consuming in vivo analysis.

Safety assessment is an important criterion for compound development before expensive preclinical and clinical studies. In order to predict Genotoxicity or specific cellular impacts, Natural Remedies provides GLP/Non-GLP in vitro genetic testing as per OECD guidelines (Mouse Lymphoma, Ames, Chromosome Aberration, Micronucleus, Steroidogenesis Assay, in-vitro Skin corrosion, Eye Irritation, Skin irritation). All work is carried out under well-defined standard operating procedures (SOPs) by highly qualified scientists.

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