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Research Bulletin
Adaptogenic Potential of PHYTOCEE® : Effect on Swim Endurance Test
Evaluation of the adaptogenic effects of PHYTOCEE in Swiss albino mice.
Figure: Effect of PHYTOCEE® on swimming time in stressed mice
Objective: To evaluate the adaptogenic effects of PHYTOCEE in Swiss albino mice.
Materials and Methods: Either sex of Swiss albino mice (n=18) aged 8-10 weeks were grouped into three containing six animals in each: G1-Normal control (Vehicle: 0.5% CMC) p.o, G2-PHYTOCEE 35 mg/kg p.o, G3-PHYTOCEE 100 mg/kg p.o. All animals were treated for 10 days. On day 10, one hour after treatment, animals were subjected to swim endurance test. The animals were allowed to swim in a tank filled with water (30 cm height and 70 cm diameter containing water up to 19 cm height, maintained at 25 ‡ 1°C). The time at which animal drown into the water was recorded and considered to be the measurement of adaptogenic activity.
Effect of PHYTOCEE® on swimming time in stressed mice
Test Groups
G1 - Normal Control
G2 - PHYTOCEE (35 mg/kg)
G3 - PHYTOCEE (100 mg/kg)
Test Duration:10 days
Increased swimming time and improved endurance.
Conclusions
Notes: Values expressed as mean + SD; n=6 *p< 0.05 as compared to G1
- PHYTOCEE® administration at 35 and 100 mg/kg for 10 days increased swimming time by 1.73 and 1.52-fold respectively as compared to normal control.
- PHYTOCEE® administration demonstrated adaptogenic effects through enhancing the physical endurance of stressed mice.